A Colonna cardinal kept his brothers' lands, the pope razed Palestrina in the fight, and a Colonna seized the pope at Anagni

On 28 April 1292 four Colonna brothers handed control of Palestrina, Zagarolo, Colonna and other family lands to their brother, Cardinal Giacomo Colonna. In 1297 three of them, Matteo, Ottone and Landolfo, complained to Pope Boniface VIII that Giacomo had disinherited them. Boniface ordered Giacomo to return the lands and hand the family's strongholds to the papacy. He refused. On 3 May 1297 his nephew Stefano Colonna seized a convoy carrying papal treasure. On 10 May Giacomo and his nephew Cardinal Pietro Colonna issued a manifesto at Lunghezza calling Boniface's election illegal, and the pope stripped both of their cardinalates the same day. On 14 December 1297 Boniface declared a crusade against the Colonna and gave command of his army to Landolfo, one of the disinherited brothers. By the end of 1298 Landolfo had captured and razed Colonna and Palestrina, and the lands were divided among him and his loyal brothers. The rest of the family fled and allied with Philip IV of France. On 7 September 1303 Sciarra Colonna and the French agent Guillaume de Nogaret broke into the papal palace at Anagni with the two deposed cardinals, seized Boniface and looted his treasury. Townspeople freed him. He died on 11 October 1303. Clement V restored the cardinals in December 1305 and revoked the sentences on 2 February 1306. Giacomo died at Avignon on 14 August 1318. The Palazzo Colonna in Rome is open to the public.